Bursa, Turkey – A team in the textile engineering department at Bursa Uludag University has developed an electrospun PU nanofibrous mat loaded with oil from nigella seeds. They believe this may improve wound healing.
Electrospun nanofibers have a natural wound healing effect because of their similarity to the extracellular matrix, while Nigella sativa oil is widely used in traditional medicine. They therefore studied the release characteristic and wound healing properties of the loaded mat, as well as its antibacterial activity and cytotoxicity.
The mat had an average fibre diameter of 416±66nm, as analysed via scanning electromicroscopy, and the oil was released at a maximum ratio of 30%. Significant activity was observed against both S. aureus and E. coli, as well as increasing cell viability in a human cell line by more than 100%.
A rat wound model showed it significantly promoted the wound healing process, with wound closure reaching about 85% compared to control on the ninth day. They concluded that the mat was a suitable candidate for a wound dressing.
The work was published in the Journal of Biomaterials Science, Polymer Edition.