Groningen, the Netherlands – Research by a medical faculty student at the University of Groningen claims that a combination of PU and polyethylene glycol (PEG) could be used to control bleeding.
Currently, hemostats are based on animal-derived products like collagen and gelatin but, according to PhD student Ferdinand Broekema, the “viscoelastic properties of PU with 55% PEG” are favourable.
He said: “Compared to collagen and gelatin, PU/PEG keeps its firmness under wet conditions whereas collagen and gelatin become formless and mushy.”
The degradation process and time of PU with 55% PEG was analysed during three years in an implantation study in rats and rabbits.
“This study showed that PU with 55% PEG has a good biocompatibility and degrades completely after three years. However, this is remarkably longer than the degradation period of collagen and gelatin.”
Broekema said that while a PU/PEG combination offered a promising alternative, “a shorter degradation period would be favourable.”